P-124 Tumor budding and CDX2 as additional prognostic factors in stage II colon cancer
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چکیده
منابع مشابه
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.
Background The identification of high-risk stage II colon cancers is key to the selection of patients who require adjuvant treatment after surgery. Microarray-based multigene-expression signatures derived from stem cells and progenitor cells hold promise, but they are difficult to use in clinical practice. Methods We used a new bioinformatics approach to search for biomarkers of colon epithelia...
متن کاملDiagnostic and prognostic microRNAs in stage II colon cancer.
MicroRNAs (miRNA) are a class of small noncoding RNAs with important posttranscriptional regulatory functions. Recent data suggest that miRNAs are aberrantly expressed in many human cancers and that they may play significant roles in carcinogenesis. Here, we used microarrays to profile the expression of 315 human miRNAs in 10 normal mucosa samples and 49 stage II colon cancers differing with re...
متن کاملAdjuvant chemotherapy and prognostic factors in stage II colon cancer--Izmir Oncology Group Study.
BACKGROUND Although adjuvant chemotherapy is a standard treatment in stage III colon cancer, its benefit is not as clear for stage II patients. In this retrospective analysis, we aimed to evaluate the survival of patients with low-risk stage II colon cancer, the efficacy of adjuvant chemotherapy in high-risk stage II colon cancer patients, and prognostic factors in stage II disease. MATERIALS...
متن کاملIntegrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer.
BACKGROUND The prognostic potential of individual clinical and molecular parameters in stage II/III colon cancer has been investigated, but a thorough multivariable assessment of their relative impact is missing. METHODS Tumors from patients (N = 1404) in the PETACC3 adjuvant chemotherapy trial were examined for BRAF and KRAS mutations, microsatellite instability (MSI), chromosome 18q loss of...
متن کاملCDX2 - A Predictive Biomarker in Stage II Colon Cancer for Adjuvant Chemotherapy?
Copyright: © 2017 Huang K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Citation: Huang K, Jennifer W. CDX2 A Predictive Biomarker in Stage II Colon Cancer for Adjuvant Chemotherapy?. Colorec Cancer....
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2020
ISSN: 0923-7534
DOI: 10.1016/j.annonc.2020.04.206